How to use sam-e depression medication

Arthritis and fibromyalgia, S-adenosylmethionine, known commercially as sam-e (pronounced Sami), is formed in the body when methionine, an amino acid, binds to the adenosine triphosphate (ATP), the largest energy source the cell.

This molecule exerts a very important role in the cycle of glutathione, a powerful antioxidant produced naturally by the body. It is essential for the proper functioning of the latter, particularly in the central nervous system and liver.

S-adenosylmethionine works closely with folic acid (vitamin B9), choline, vitamins B6 and B12. These substances are described as "methyl donors." These reactions required to participate in the methylation process protection. A deficiency in these vitamins can lower the natural rate of sam-e in the body. It seems that people with too low a rate of sam-e in the blood are more prone to depression, joint problems and chronic liver disease.

Methyl donors also play an important protective role against cancer, cardiovascular disease, neurological disorders and aging.

The use of sam-e in supplement form has many advantages backed by serious scientific studies. It would be effective in a variety of conditions, mainly in the following cases:

    Depression
    Osteoarthritis
    Fibromyalgia
    Hepatitis, liver cirrhosis

Depression

Clinical trials and studies, the supplement sam-e was more effective than placebo and as effective as tricyclic antidepressants like imipramine and amitriptyline.
sam-e stimulates the production of neurotransmitters such as dopamine, serotonin and norepinephrine, hormones that are regarded as neurotransmitters act as mood stabilizers.

It takes usually 4 to 6 weeks to notice an improvement, but it may be faster in some cases. The recommended dose is 400 to 1600 mg per day. It is advisable to start with a dose of 200 mg twice daily, and gradually increase the dose to 1200 mg per day (some studies have used up to 1,600 mg per day).
People suffering from manic depression, bipolar shape, should not consume supplement sam-e.

Ostéoarthite and fibromyalgia

After using supplements of sam-e to treat depression, researchers have discovered that he also improved the problems of arthritis, osteoarthritis. This efficiency has been verified in clinical trials or sam-e was more effective than placebo and as effective as traditional anti-inflammatory, such as Celebrex ®.
The recommended dose is 1200 mg to 1600 mg per day divided into two or three doses.
Clinical trials in Italy and Denmark promise for improving the condition of people suffering from fibromyalgia. Doses of 800 mg per day have been used.

Homocysteine and sam-e

In 1992, researchers at Harvard have shown that men who have a blood homocysteine ​​levels 12% higher than the average, have a risk 3.4 times greater of having a heart attack. When the body has an adequate supply of B vitamins, particularly: folic acid, vitamin B6, vitamin B12 and choline, sam-e helps lower blood homocysteine ​​levels. By cons in case of deficiency in these vitamins, sam-e may actually increase the rate of homocysteine.

Use and care

The supplement sam-e is generally well tolerated. There may be some people small gastrointestinal problems and nausea, especially at high doses. There is also some cases of insomnia and for this reason it is recommended to take the supplement in the morning and take the last dose before bed long enough.

It is also advised to take the supplement sam-e on an empty stomach.
Promote enteric coated capsules that allow better absorption of the supplement.

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